Figure 15.

(A) Overlay of Polλ in the binary and ternary conformations. DNA is shown in light blue, and Loop 1 is shown in purple. (B) Differences in Loop 1 orientation between the two conformations. Distance between position 438 and Loop 1 following an interpolation between the two structures at its (D) furthest and (C) closest approaches. Reproduced from Swett, R. J., Elias, A., Miller, J. A., Dyson, G. E., and Cisneros, G. A. (2013) Hypothesis driven single nucleotide polymorphism search (HyDnSNP-S). In DNA Repair12, 733–740, Copyright 2013, with permission from Elsevier.¹⁰⁴