Figure 2.

Catalytically relevant residues in Polλ. Residues colored in red have large energetic contributions to transition state stability or are present in all transition states, residues in green correspond to the QM subsystem. Reprinted from Cisneros, G. A., Perera, L., García-Díaz, M., Bebenek, K., Kunkel, T. A., and Pedersen, L. G. (2008) Catalytic mechanism of human DNA polymerase λ with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies. In DNA Repair, Vol. 7, pp 1824–1834, Copyright 2008, with permission from Elsevier.⁵⁶