Figure 9.

Schematic diagram of the proposed fidelity checking process in DNA polymerase I. Following nucleotide insertion, the DNA is translocated to the checking site. If the inserted base pair is a correct pair, the polymerase continues. If not, the DNA is shifted to the exonuclease domain and the incorrect base pair is excised. Reproduced from Graham, S.E., Syeda, F., and Cisneros, G. A. (2012) Computational Prediction of Residues Involved in Fidelity Checking for DNA Synthesis in DNA Polymerase I. Biochemistry51, 2569–2578. Copyright 2012 American Chemical Society.⁹³