Table 5.
Critical amino acid residues involved in interactions with the four inhibitors (amino acid residues common to docking results in italics, new interacting residues after MD simulation in bold).
Tannic Acid | Sennoside B | Rhein | Danthron | |
---|---|---|---|---|
Residues | Val350, Arg351, Ile365, Leu366, His367, Ser368, Arg389, Ser390, Leu391, Ser424, Ser425, Glu427, Glu428, Trp434. | Val350, Arg351, Ile365, Leu366, His367, Ser368, Ser425, Ile426, Glu428, Glu427, Trp434. | Arg351, Arg389, Ser390, Leu391, Ser425, Glu428, Gly392. | Val350, Arg351, Val363, Ile365, Leu366, Trp373, Val386, Val387, Ser390, Ser424, Ser425, Ile426. |