. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Br J Haematol. 2017 Sep 7;179(4):648–656. doi: 10.1111/bjh.14918

Table I.

Clinical Characteristics and Laboratory Data

	Controls n=27	SCD - HC n=6	SCD + HC n=15
Age (median, years [IQR])	27 (23–44)	32 (24–35)	35 (27–46)
Gender (%female)	41	50	53
BMI (kg/m²)	27 ± 5	23 ± 7	23 ± 3^*
Baseline heart rate (/min)	62 ± 12	71 ± 10	66 ± 9
Baseline systolic BP (mmHg)	117 ± 11	113 ± 14	114 ± 12
Baseline diastolic BP (mmHg)	63 ± 10	59 ± 6	63 ± 9
Creatinine (µmol/l)	88.4 ± 17.7	53.0 ± 8.8^*	61.9 ± 35.4^***
Glucose (mmol/l)	5.3 ± 0.8	5.1 ± 1.1	5.3 ± 0.9
Total bilirubin (µmol/l)	8.6 ± 5.1	53.0 ± 12.0^***	44.5 ± 30.8^***
Alkaline phosphatase (u/l)	65 ± 16	122 ± 39^**	82 ± 21
LDH (u/l)	181 ± 33	513 ± 156^***	427 ± 135^***
WBC (10⁹/l)	4.9 ± 1.3	10.0 ± 2.1^***	6.7 ± 2.1 ^*
Hemoglobin (g/l)	132 ± 13	79 ± 11^***	94 ± 14^***
MCV (fl)	84.9 ± 6.1	82.5 ± 8.6	103.6 ± 11.5^***^{^^}
Reticulocyte Count (%)	1.4 ± 0.4	15.7 ± 5.6^***	9.3 ± 3.4^***

p<0.05,

^**

p<0.01,

^***

p<0.001 for controls vs SCD

^{^}

p<0.05,

^{^^}

p<0.01 for SCD vs SCD+HC

BMI: body mass index; BP: blood pressure; HC: hydroxycarbamide; IQR: interquartile range; LDH: lactate dehydrogenase; MCV: mean corpuscular volume; SCD: sickle cell disease; WBC: white blood cell.