Table 3.
Direct and Indirect effects seen in the final SEM model shown in Figure 2.
| Type of effect | Path | Estimate (std. error) |
p-value |
|---|---|---|---|
| Total | Age to CMC | 0.616 (0.080) | <0.001 |
| Direct | Age to CMC | 0.616 (0.080) | <0.001 |
|
| |||
| Total | Male to CMC | 0.287 (0.136) | 0.034 |
| Direct | Male to CMC | 0.287 (0.136) | 0.034 |
|
| |||
| Total | Age to Amyloid | 0.446 (0.050) | <0.001 |
| Direct | Age to Amyloid | 0.446 (0.050) | <0.001 |
|
| |||
| Total | APOE to Amyloid | 0.612 (0.095) | <0.001 |
| Direct | APOE to Amyloid | 0.612 (0.095) | <0.001 |
|
| |||
| Total | Age to Tau | 0.289 (0.036) | <0.001 |
| Total Indirect | Age to Tau | 0.289 (0.036) | <0.001 |
| Indirect | Age to Amyloid to Tau | 0.247 (0.033) | <0.001 |
| Indirect | Age to CMC to Tau | 0.041 (0.017) | 0.016 |
|
| |||
| Total | Male to Tau | 0.019 (0.012) | 0.105 |
| Indirect | Male to CMC to Tau | 0.019 (0.012) | 0.105 |
|
| |||
| Total | APOE to Tau | 0.340 (0.058) | <0.001 |
| Indirect | APOE to Amyloid to Tau | 0.340 (0.058) | <0.001 |
|
| |||
| Total | CMC to Tau | 0.067 (0.027) | 0.012 |
| Direct | CMC to Tau | 0.067 (0.027) | 0.012 |
|
| |||
| Total | Amyloid to Tau | 0.555 (0.040) | <0.001 |
| Direct | Amyloid to Tau | 0.555 (0.040) | <0.001 |
|
| |||
| Total | Age to Neurodegeneration | 0.630 (0.047) | <0.001 |
| Direct | Age to Neurodegeneration | 0.513 (0.050) | <0.001 |
| Total Indirect | Age to Neurodegeneration | 0.117 (0.023) | <0.001 |
| Indirect | Age to Amyloid to Tau to Neurodegeneration | 0.051 (0.012) | <0.001 |
| Indirect | Age to CMC to Neurodegeneration | 0.057 (0.018) | 0.002 |
| Indirect | Age to CMC to Tau to Neurodegeneration | 0.009 (0.004) | 0.029 |
|
| |||
| Total | Male to Neurodegeneration | 0.216 (0.078) | 0.006 |
| Direct | Male to Neurodegeneration | 0.186 (0.077) | 0.016 |
| Total Indirect | Male to Neurodegeneration | 0.031 (0.017) | 0.064 |
| Indirect†† | Male to CMC to Neurodegeneration | 0.013 (0.007) | 0.072 |
| Indirect†† | Male to CMC to Tau to Neurodegeneration | 0.002 (0.001) | 0.120 |
|
| |||
| Total | APOE to Neurodegeneration | 0.070 (0.018) | <0.001 |
| Indirect | APOE to Amyloid to Tau to Neurodegeneration | 0.070 (0.018) | <0.001 |
|
| |||
| Total | CMC to Neurodegeneration | 0.107 (0.028) | <0.001 |
| Direct | CMC to Neurodegeneration | 0.093 (0.027) | 0.001 |
| Indirect | CMC to Tau to Neurodegeneration | 0.014 (0.006) | 0.023 |
|
| |||
| Total | Amyloid to Neurodegeneration | 0.115 (0.024) | <0.001 |
| Indirect | Amyloid to Tau to Neurodegeneration | 0.115 (0.024) | <0.001 |
|
| |||
| Total | Tau to Neurodegeneration | 0.207 (0.040) | <0.001 |
| Direct | Tau to Neurodegeneration | 0.207 (0.040) | <0.001 |
††
These indirect effects are not in the final model; coefficients and p-values are from the saturated model.