Table 1.
Clinicopathologic Characteristics in Patients with Pulmonary Recurrence Based on Subsequent Treatment
| Variable | No Surgery n=200 (%) | Repeat PM n=141 (%) | P |
|---|---|---|---|
| Sex | 0.179 | ||
| Female | 126 (63.0) | 78 (55.3) | |
| Male | 74 (37.0) | 63 (44.7) | |
| Age at diagnosis of primary tumora | 53.0 (41.6, 62.4) | 48.0 (36.0, 56.7) | <0.001 |
| Histologic subtype of primary tumor | 0.002 | ||
| PS/MFH | 59 (29.5) | 21 (14.9) | |
| Synovial | 21 (10.5) | 32 (22.7) | |
| Leiomyosarcoma | 71 (35.5) | 42 (29.8) | |
| Liposarcoma | 10 (5.0) | 9 (6.4) | |
| Fibrosarcoma | 8 (4.0) | 14 (9.9) | |
| MPNST | 5 (2.5) | 4 (2.8) | |
| Other | 26 (13.0) | 19 (13.5) | |
| Site of primary tumor | 0.087 | ||
| Extremity | 96 (48.0) | 71 (50.4) | |
| Trunk | 25 (12.5) | 13 (9.2) | |
| Retroperitoneal/abdomen/pelvis | 24 (12.0) | 10 (7.1) | |
| Visceral-GU/GYN | 51 (25.5) | 37 (26.2) | |
| Head and neck | 4 (2.0) | 10 (7.1) | |
| Size of primary tumor | 0.107 | ||
| ≤10 cm | 97 (48.5) | 75 (53.2) | |
| >10 cm | 90 (45.0) | 50 (35.5) | |
| Unknown | 13 (6.5) | 16 (11.3) | |
| Grade of primary tumor | 0.230 | ||
| Low | 16 (8.0) | 18 (12.8) | |
| High | 180 (90.0) | 122 (86.5) | |
| Unknown | 4 (2.0) | 1 (0.7) | |
| Interval to first PM | 0.128 | ||
| Synchronous | 29 (14.5) | 17 (12.1) | |
| <12 months | 74 (37.0) | 40 (28.4) | |
| ≥12 months | 97 (48.5) | 84 (59.6) | |
| Type of surgery at first PM | 0.002 | ||
| Open | 155 (77.5) | 87 (61.7) | |
| Minimally invasive | 45 (22.5) | 54 (38.3) | |
| Extent of resection at first PM | 0.064 | ||
| Wedge | 151 (75.5) | 121 (85.8) | |
| Lobectomy | 45 (22.5) | 18 (12.8) | |
| Pneumonectomy | 4 (2.0) | 2 (1.4) | |
| Disease-free intervalb | <0.001 | ||
| <12 months | 175 (87.5) | 98 (69.5) | |
| ≥12 months | 25 (12.5) | 43 (30.5) | |
| Number pulmonary nodules at recurrence | <0.001 | ||
| 1 | 42 (21.0) | 70 (49.6) | |
| 2 | 25 (12.5) | 21 (14.9) | |
| 3 | 43 (21.5) | 15 (10.6) | |
| 4 | 24 (12.0) | 6 (4.3) | |
| 5 | 7 (3.5) | 1 (0.7) | |
| >5 | 42 (21.0) | 20 (14.2) | |
| Unknown | 17 (8.5) | 8 (5.6) | |
| Synchronous extrapulmonary disease at recurrence | <0.001 | ||
| No | 74 (37.0) | 110 (78.0) | |
| Yes | 126 (63.0) | 31 (22.0) | |
| KPS scale at recurrence | <0.001 | ||
| ≤70 | 18 (9.0) | 0 (0.0) | |
| 80 | 45 (22.5) | 12 (8.5) | |
| 90 | 77 (38.5) | 71 (50.4) | |
| 100 | 19 (9.5) | 15 (10.6) | |
| Unknown | 41 (20.5) | 43 (30.5) |
GU, genitourinary; GYN, gynecological; MPNST, malignant peripheral nerve sheath tumor; PM, pulmonary metastasectomy; PS/MFH, pleomorphic sarcoma/malignant fibrous histiocytoma; KPS, Karnofsky Performance Status.
a
Represented as median (25th, 75th percentile)
b
From first pulmonary metastasectomy to recurrence at any site.