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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Brain Behav Immun. 2017 Jul 21;67:13–23. doi: 10.1016/j.bbi.2017.07.017

Figure 3. Serum estradiol levels correlated with latency to epileptiform activity in the hippocampus.

Figure 3

(A) Correlation of serum estradiol concentrations and latency to hippocampal epileptiform activity after efflux transporter inhibition (n = 9). The higher the serum levels of estradiol, the shorter the latency to epileptiform discharges within the hippocampus in response to efflux transporter inhibition. The dotted line represents an estimated estradiol serum threshold; Nonpreg rats with estradiol levels below threshold did not develop epileptiform discharges. (B) Correlation of serum estradiol concentrations and latency to behavioral seizure onset after efflux transporter inhibition (n = 12). * p < 0.05 by linear regression analysis and Pearson’s correlation.