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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Genet Epidemiol. 2017 Oct 29;41(8):824–833. doi: 10.1002/gepi.22084

Figure 2. QQ-plots of individual p-values for various associations in Normative Aging genome-wide Study.

Figure 2

A) P-values from pack-years to DNAm B) P-values from DNAm to FEV1 adjusting for pack-years C) Testing DNA methylation as a mediator for the association between pack years and lung function using the joint significance approach D) Testing DNA methylation as a mediator for the association between pack years and lung function using product p-value with Sobel variance estimate.