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. Author manuscript; available in PMC: 2018 Nov 20.
Published in final edited form as: Chem Res Toxicol. 2017 Oct 23;30(11):2023–2032. doi: 10.1021/acs.chemrestox.7b00227

Figure 5.

Figure 5

Structures of LdG-harboring DNA within pol κ-bound complexes at the (A) insertion and (B) extension stages. The color scheme of the left and middle panels is the same as described in Figure 4. Incoming dNTP* is in yellow, where dNTP* is dCMPNPP (dCTP*) or dAMPNPP (dATP*). The double arrowed lines illustrate a distance of 4.3–4.5 Å between the 3′–OH of the primer and the α phosphate of dNTP*. In both insertion and extension complexes, the lucidin ring is oriented toward the 3′-end of the template strand. The right panels illustrate the superposition of LdG-containing DNA with unmodified DNA in a pol κ complex (PDB codes: 2OHO). The unmodified DNA is in gray and the adducted DNA (LdG adduct in orange) is in cyan (insertion stage) and blue (extension stage).