Skip to main content
. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Curr Opin Chem Biol. 2017 Sep 20;40:127–137. doi: 10.1016/j.cbpa.2017.07.008

Figure 1. Biosynthesis of Lipid A in E. coli.

Figure 1

(Adapted from [4]) The enzymes LpxA, LpxC, and LpxD are located in the cytoplasm, whereas LpxH, LpxB, LpxK, WaaA, LpxL and LpxM are anchored to the inner membrane. Substrates for the biosynthetic are highlighted in green: acyl carrier protein (ACP)-bound acyl donors, UDP-N-acetylglucosamine (UDP-GlcNAc), ATP, and CMP-3-deoxy-D-manno-octulosonic acid (CMP-Kdo). The product of the pathway is further modified into variable lipopolysaccharide structures via further glycosylation of the Kdo sugars (not explicitly shown).