. Author manuscript; available in PMC: 2018 Dec 15.

Published in final edited form as: Anal Biochem. 2017 Oct 18;539:81–89. doi: 10.1016/j.ab.2017.10.014

Table 7.

Potency of various inhibitors for carboxylesterases and selected serine hydrolases. Inhibitor potencies (IC₅₀) were measured at 37°C in phosphate buffer (100 mM, pH = 8, 0.1 mg/mL BSA) containing ≤2% DMSO using either CMNA (hCE1, hCE2, hCE3, AADAC, PON1) or 1b (FAAH) as the substrate ([S]_final= 50 µM). Values represent the average of triplicates for a single experiment.

	IC₅₀ (µM)

	2-chloro-3’,4’- dimethoxybenzil	Loperamide	Thyroxine

hCE1	2.5	>100	1.5
hCE2	0.014	0.65	16
hCE3	>100	>100	23
AADAC	>100	23	0.73
FAAH	7.6	>100	>100
PON1	25	>100	2.1
Selectivity hCE2/hCE1	180	>150	0.094