Table 2. HDL-associated proteins that differed across estimated GFR categories.

Protein	Model	eGFR 60+	eGFR 45-60	eGFR 30-45	eGFR 15-30	eGFR < 15	p
RBP4	Median(IQR)	0.38(0.24,0.57)	0.42(0.30,0.66)	0.61(0.40,0.90)	0.67(0.39,0.93)	0.79(0.50,1.25)
	M1	1.00 (ref)	1.05(0.83,1.33)	1.54(1.22,1.96)	1.59(1.25,2.01)	1.94(1.40,2.70)	<0.0001
	M2	1.00 (ref)	1.05(0.83,1.33)	1.53(1.20,1.94)	1.60(1.26,2.04)	1.89(1.34,2.67)	<0.0001
APOC3	Median(IQR)	1.36(1.02,1.82)	1.56(1.11,2.07)	1.73(1.21,2.42)	1.82(1.29,2.38)	2.16(1.38,3.16)
	M1	1.00 (ref)	1.10(0.96,1.26)	1.24(1.09,1.42)	1.22(1.07,1.39)	1.51(1.25,1.82)	<0.0001
	M2	1.00 (ref)	1.10(0.96,1.26)	1.25(1.09,1.43)	1.24(1.08,1.42)	1.52(1.25,1.84)	<0.0001
CETP	Median(IQR)	2.11(1.29,3.55)	2.15(1.21,3.43)	1.97(1.35,2.80)	1.85(1.09,2.87)	1.26(0.81,2.35)
	M1	1.00 (ref)	0.91 (0.73,1.13)	0.86 (0.69,1.08)	0.74 (0.60,0.93)	0.66 (0.48,0.89)	0.0008
	M2	1.00 (ref)	0.90 (0.72,1.13)	0.86 (0.69,1.08)	0.77 (0.61,0.96)	0.64 (0.46,0.88)	0.0023
VIT	Median(IQR)	0.94 (0.70,1.30)	0.86 (0.62,1.18)	0.85 (0.55,1.27)	0.74 (0.53,1.05)	0.71 (0.52,0.92)
	M1	1.00 (ref)	0.85 (0.71,1.02)	0.83 (0.70,1.00)	0.73 (0.61,0.87)	0.70 (0.55,0.90)	0.0001
	M2	1.00 (ref)	0.85 (0.71,1.01)	0.84 (0.70,1.00)	0.75 (0.62,0.90)	0.71 (0.55,0.92)	0.0008
APOL1	Median(IQR)	1.11 (0.63,1.72)	1.14 (0.72,1.75)	0.99 (0.54,1.47)	0.87 (0.37,1.32)	0.78 (0.54,1.29)
	M1	1.00 (ref)	1.02 (0.83,1.24)	0.84 (0.68,1.02)	0.70 (0.57,0.85)	0.59 (0.45,0.78)	<0.0001
	M2	1.00 (ref)	1.02 (0.83,1.24)	0.88 (0.72,1.07)	0.73 (0.59,0.89)	0.64 (0.48,0.85)	<0.0001

Relative abundance of HDL-associated proteins that varied as a function of eGFR. Absolute protein abundance is presented as well as adjusted models normalized to subject group with eGFR>60 mL/min/1.73m². M1: adjusted for age, race (black vs. other), sex, prevalent diabetes, BMI, current smoking status, statin use, HDL, total cholesterol, and triglycerides. M2: Adjusted for all variables in M1 and albuminuria. Data are presented as median (interquartile range). HDL=high-density lipoprotein, GFR=glomerular filtration rate, RBP4=retinol-binding protein 4, APOC3=apolipoprotein C-III, CETP=cholesteryl ester transfer protein, VIT=vitronectin,APOL1 =apolipoprotein L1