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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Brain Behav Immun. 2017 Sep 28;67:355–363. doi: 10.1016/j.bbi.2017.09.016

Figure 2. Severe stress increases hippocampal IL-1β immunoreactivity.

Figure 2

The stress-induced increase in hippocampal IL-1β that we previously reported is replicated here. Representative images of IL-1β immunoreactivity in the dentate gyrus of the DH acquired at 10X are shown from stressed (Foot Shock in context A) and non-stressed (No Foot Shock in Context A) rats. Top panel shows a tiled 10X image, while bottom panel shows a single 10X image. For the bottom panel, Bitplane Imaris was used for background subtraction to better visualize individual cells presented. Paxinos and Watson (2007) schematic shows the approximate region of the DH where images were acquired, AP −3.36 from bregma. Quantification of IL-1β immunoreactivity revealed that exposure to severe stress (15 foot shocks) significantly increased IL-1β immunoreactivity in the DH 48 hours post-stress. * p < 0.05.