Table 4.
Summary of systemic metabolite concentrations at baseline (mM) and of mixed effects model results. The model coefficient results are presented as a percent change from baseline concentrations for each metabolite assuming a 100% increase in baseline lactate, following the t-value, degrees of freedom (DF), p-value, and number of patients and number of readings available for the analysis.
| Metabolite | Baseline concentration (mM) |
Mixed effects model | |||
|---|---|---|---|---|---|
| Coefficient (% change from baseline) |
t-value (DF) |
p-value | # patients (# readings) | ||
| Glucose | 7.54 [6.46 8.62] |
2 [−1 6] |
1.5 (36) | 0.13 | 11 (48) |
| Alanine | 0.17 [0.12 0.21] |
30 [20 39] |
6.4 (33) | <0.001 | 11 (45) |
| Pyruvate | 0.030 [NA 0.061] |
33 [−1 68] |
2.1 (11) | 0.057 | 5 (17) |
| Glutamine | 0.26 [0.18 0.33] |
34 [24 43] |
7.1 (30) | <0.001 | 10 (41) |
| Acetate | 0.063 [0.042 0.085] |
87 [60 113] |
6.8 (23) | <0.001 | 9 (33) |
| Valine | 0.18 [0.12 0.24] |
40 [28 51] |
7.1 (32) | <0.001 | 11 (44) |
| Leucine | 0.10 [0.08 0.13] |
24 [16 32] |
6.1 (33) | <0.001 | 11 (45) |
| Acetoacetate | 0.075 [NA 0.172] |
−2 [−17 12] |
−0.3 (17) | 0.76 | 7 (25) |
| β-hydroxybutyrate | 0.149 [NA 0.382] |
16 [−11 42] |
1.2 (18) | 0.23 | 7 (26) |