Table 1A. Meta-analysis results for associations between the TLRs and overall survival for NSCLC patients.*.
| Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Affy Probe ID | n | P value | HR^ | P value (gene)** | HR (gene) | P value (histology) | P value (gender) |
| TLR1 | 210176_at | 1926 | 6.50E-05 | 0.72 (0.61-0.85) | 0.003 | 0.74 (0.63 0.87) | 1.00E-15 | 0.0004 |
| TLR2 | 204924_at | 1926 | 5.40E-09 | 0.61 (0.52-0.72) | 6.00E-04 | 0.74 (0.62-0.88) | 1.00E-15 | 0.0006 |
| TLR3 | 206271_at | 1926 | 4.20E-07 | 0.66 (0.56-0.77) | 0.0052 | 0.78(0.66-0.93) | 1.00E-15 | 0.0003 |
| TLR4 | 232068_s_at | 1587 | ns | 0.85 (0.71-1.03) | ns | - | - | - |
| TLR5 | 210166_at | 1926 | 1.80E-05 | 0.7 (0.59-0.82) | 0.0173 | 0.81 (0.68 0.96) | 1.00E-15 | 0.0005 |
| TLR6 | 239021_at | 1926 | 5.50E-06 | 0.64 (0.53-0.78) | 0.001 | 0.72 (0.59 0.87) | 1.00E-15 | 0.0017 |
| TLR7 | 220146_at | 1926 | 6.60E-10 | 0.6 (0.51-0.71) | 1.00E-15 | 0.6 (0.51-0.71) | 1.00E-15 | 0.0006 |
| TLR8 | 229560_at | 1587 | 0.00022 | 0.7 (0.58-0.85) | 0.0095 | 0.78 (0.64-0.94) | 1.00E-15 | 0.0024 |
| TLR9 | 223903_at | 1587 | ns | 0.94 (0.78-1.13) | ns | - | - | - |
| TLR10 | 223751_x_at | 1926 | ns | 0.85 (0.71-1.03) | ns | - | - | - |
* For all significant TLRs, FDR 5% was tested, NSCLC combined samples P <0.0173; ADC samples P <0.0066; ** Multivariate for all NSCLC for gender and histology; ^ Hazard ratio. Ns, not significant. Dash indicates test was not performed due to non-significance in univariate analysis.