Table 1B. Meta-analysis results for associations between the TLRs and overall survival for ADC patients.*.
| Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Affy Probe ID | n | P value | HR^ | P value (gene)** | HR (gene) | P value (stage) | P value (gender) |
| TLR1 | 210176_at | 720 | 1.50E-03 | 0.63 (0.47-0.84) | 0.0029 | 0.65 (0.48 - 0.86) | 1.00E-15 | ns |
| TLR2 | 204924_at | 720 | 1.60E-08 | 0.43 (0.32-0.58) | 1.00E-15 | 0.45 (0.33-0.6) | 1.00E-15 | ns |
| TLR3 | 206271_at | 720 | 3.00E-04 | 0.59 (0.44-0.79) | 0.0028 | 0.64 (0.48-0.86) | 1.00E-15 | ns |
| TLR4 | 232068_s_at | 673 | ns | 0.76 (0.56-1.03) | - | - | - | - |
| TLR5 | 210166_at | 720 | 0.0057 | 0.67 (0.5-0.89) | 0.0066 | 0.67 (0.5 - 0.89) | 1.00E-15 | ns |
| TLR6 | 239021_at | 720 | 0.00054 | 0.58 (0.43-0.79) | 0.0049 | 0.64 (0.46 - 0.87) | 1.00E-15 | ns |
| TLR7 | 220146_at | 720 | 2.90E-11 | 0.37 (0.27-0.5) | 1.00E-15 | 0.41 (0.3 - 0.57) | 1.00E-15 | ns |
| TLR8 | 229560_at | 720 | 0.0027 | 0.69 (0.54-0.88) | 0.0014 | 0.6 (0.43-0.82) | 1.00E-15 | ns |
| TLR9 | 223903_at | 673 | ns | 1.17 (0.87-1.59) | ns | - | - | - |
| TLR10 | 223751_x_at | 720 | ns | 0.97 (0.78-1.23) | - | - | - | - |
* For all significant TLRs, FDR 5% was tested, ADC combined samples P <0.0066; ** Multivariate for ADC for gender and stage; ^ Hazard ratio. Ns, not significant. Dash indicates test was not performed due to non-significance in univariate analysis.