Table 8. Association analysis of polymorphisms in pre-miR-146a, pre-miR-196a-2 and pre-miR-499 genes in patients with SLE; no nephritis vs nephritis.
| Gene SNP | No nephritis | Lupus nephritis | OR | 95% CI | p |
|---|---|---|---|---|---|
| miR-146a | n=112 (%) | n=90 (%) | |||
| rs2910164 | |||||
| Genotype | |||||
| GG | 41 (36.6) | 38 (42.3) | — | — | — |
| GC | 47 (42.0) | 40 (44.4) | 0.92 | 0.50-1.69 | 0.784 |
| CC | 24 (21.4) | 12 (13.3) | 0.54 | 0.24-1.23 | 0.139 |
| Allele | |||||
| G | 129 (57.6) | 116 (64.4) | — | — | — |
| C | 95 (42.4) | 64 (35.6) | 0.75 | 0.50-1.12 | 0.161 |
| miR-196a-2 | n=112 (%) | n=90 (%) | |||
| rs11614913 | |||||
| Genotype | |||||
| CC | 46 (41.1) | 38 (42.3) | — | — | — |
| CT | 44 (39.3) | 40 (44.4) | 1.10 | 0.60-2.02 | 0.757 |
| TT | 22 (19.6) | 12 (13.3) | 0.66 | 0.29-1.51 | 0.322 |
| Allele | |||||
| C | 136 (60.7) | 116 (64.4) | — | — | — |
| T | 88 (39.3) | 64 (35.6) | 0.85 | 0.57-1.28 | O.442 |
| miR-499 | n=112 (%) | n=90 (%) | |||
| rs3746444 | |||||
| Genotype | |||||
| AA | 94 (83.9) | 77 (85.6) | — | — | — |
| AG | 18 (16.1) | 13 (14.4) | 0.88 | 0.41-1.91 | 0.750 |
| GG | 0 (0.0) | 0 (0.0) | 1.22 | 0.02-62.16 | 1.000 |
| Allele | |||||
| A | 206 (92.0) | 167 (92.8) | — | — | — |
| G | 18 (8.0) | 13 (7.2) | 0.89 | 0.42-1.87 | 0.760 |
OR: odds ratio; CI: confidence interval; p: p value; SLE: systemic lupus erythematosus.