Figure 7. The morphological changes of aluminum overload primary cultured hippocampus neuron treated by different concentrations of EP_1-4 agonist or antagonist.

The photograph showed the number and structure of neurons in (A) control group (maltol 300 μM) and (B) aluminum overload group (Al(mal)₃100 μM). (C) Al(mal)₃100 μM + 10 μM 17-phenyl trinor Prostaglandin E2 ethyl amide-treated group, (D) Al(mal)₃100 μM + 10 μM AH6809-treated group and (F) Al(mal)₃100 μM + 10 μM L-161982–treated group decreased the number and structure of neurons in the model group, whereas (E) Al(mal)₃100 μM + 10 μM Sulprostone-treated group increased the number and structure of neurons in the Al(mal)₃-treated group. Sections were pictured at 400×.