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. 2017 Sep 6;8(54):92043–92054. doi: 10.18632/oncotarget.20664

Figure 3. Cofilin 1 inhibits apoptosis and promotes cell cycle progression, migration, invasion, and adhesion.

Figure 3

(A and B) Apoptosis analysis for T24 and RT4 cells transfected with different vectors. Cells were stained with Annexin V-FITC/PI and analyzed by flow cytometry to determine early and late apoptosis cell populations. Percentages of apoptotic cells in each group relative to total cell numbers were used to evaluate apoptosis rates. (C and D) Cell cycle population changes in T24 and RT4 cells transfected with different vectors were assessed by flow cytometry using PI staining to measure the DNA content. (E and F) Migration and invasion capacity of T24 and RT4 cells transfected with Cofilin 1 and si-Cofilin 1. (G and H) Invasion capacity and cell adhesion in T24 and RT4 cells transfected with Cofilin 1 and si-Cofilin 1. (I and J) Cell adhesion capacity in T24 and RT4 cells transfected with Cofilin 1 and si-Cofilin 1. The data are presented as the means of three independent experiments, *p < 0.01.