Figure 3. Small animal PET imaging of ⁶⁴Cu-PCTA-cetuximab in SNU-1066 HNSCC xenograft model.

PET images were acquired at 2 h, 24 h and 48 h after injection of 64Cu-PCTA-cetuximab and represented as SUV. (a) ⁶⁴Cu-PCTA-cetuximab was selectively localized in SNU-1066 tumor. After PET imaging, mice were immediately frozen and sectioned, and frozen section photo and digital whole body autoradiography (DWBA) images were obtained. (b) In blocking experiments, ⁶⁴Cu-PCTA-cetuximab uptake in tumor was markedly reduced by pre-treated cold excess cetuximab. Tumors are indicated by white dotted circles. T, SNU-1066 tumor; L, liver.