Table 3. Extrapolated radiation dosimetry to an adult human after intravenous injection of 177Lu-PCTA-cetuximab based on the biodistribution data obtained in SNU-1066 xenograft model.
| Organ | mGy/MBq | rad/mCi | ||||
|---|---|---|---|---|---|---|
| Adrenals | 7.3E-05 | ± | 4.6E-06 | 2.7E-04 | ± | 1.7E-05 |
| Brain | 2.9E-07 | ± | 1.8E-08 | 1.1E-06 | ± | 6.6E-08 |
| Breasts | 2.9E-04 | ± | 1.5E-05 | 1.1E-03 | ± | 5.5E-05 |
| LLI * | 2.8E-03 | ± | 1.8E-03 | 1.0E-02 | ± | 6.6E-03 |
| Small Intestine | 5.5E-04 | ± | 3.5E-04 | 2.0E-03 | ± | 1.3E-03 |
| Stomach | 3.7E-03 | ± | 8.6E-04 | 1.4E-02 | ± | 3.2E-03 |
| ULI ** | 2.9E-05 | ± | 5.1E-06 | 1.1E-04 | ± | 1.9E-05 |
| Kidneys | 5.7E-03 | ± | 3.1E-04 | 2.1E-02 | ± | 1.2E-03 |
| Liver | 6.0E-02 | ± | 4.5E-03 | 2.2E-01 | ± | 1.7E-02 |
| Lungs | 7.7E-02 | ± | 6.1E-03 | 2.9E-01 | ± | 2.3E-02 |
| Muscle | 1.6E-05 | ± | 1.2E-06 | 5.8E-05 | ± | 4.4E-06 |
| Ovaries | 8.6E-04 | ± | 2.8E-04 | 3.2E-03 | ± | 1.0E-03 |
| Pancreas | 1.1E-04 | ± | 9.6E-06 | 3.9E-04 | ± | 3.6E-05 |
| Red Marrow | 8.2E-04 | ± | 6.5E-05 | 3.0E-03 | ± | 2.4E-04 |
| Osteogenic Cells | 8.3E-05 | ± | 5.8E-06 | 3.1E-04 | ± | 2.2E-05 |
| Skin | 2.5E-05 | ± | 1.7E-06 | 9.3E-05 | ± | 6.2E-06 |
| Spleen | 2.3E-01 | ± | 3.1E-02 | 8.7E-01 | ± | 1.2E-01 |
| Thymus | 1.9E-05 | ± | 7.9E-07 | 7.2E-05 | ± | 2.9E-06 |
| Thyroid | 6.3E-05 | ± | 3.8E-06 | 2.3E-04 | ± | 1.4E-05 |
| Urinary Bladder | 5.8E-05 | ± | 1.6E-05 | 2.1E-04 | ± | 5.9E-05 |
| Uterus | 9.2E-06 | ± | 3.0E-06 | 3.4E-05 | ± | 1.1E-05 |
| Whole body | 3.9E-01 | 1.4E+00 | ||||
* LLI; lower large intestine, **; upper large intestine.