Table 2. Genetic polymorphisms and risk of lung cancer.
Genotype | Lung cancer cases (%) | Controls (%) | P of HWE | Adjusted OR a | 95% CI | P | |
---|---|---|---|---|---|---|---|
Rs1049337 | TT | 133 (28.4) | 118(25.9) | 0.061 | Ref | ||
TC | 234 (50.0) | 207(45.5) | 1.006 | 0.738,1.373 | 0.968 | ||
CC | 101 (21.6) | 130(28.6) | 0.691 | 0.482,0.990 | 0.044* | ||
Dominant model | 0.882 | 0.659,1.179 | 0.395 | ||||
Recessive model | 0.688 | 0.510,0.929 | 0.015* | ||||
Additive model | C allele | 0.829 | 0.691,0.995 | 0.045* | |||
Rs926198 | TT | 425(90.8) | 385(84.6) | 0.506 | Ref | ||
TC | 42(9.0) | 69(15.2) | 0.552 | 0.367,0.830 | 0.004* | ||
CC | 1(0.2) | 1(0.2) | 0.910 | 0.056,14.674 | 0.947 | ||
Dominant model | 0.557 | 0.372,0.834 | 0.005* | ||||
Recessive model | 1.007 | 0.251,4.042 | 0.992 | ||||
Additive mode | C allele | 0.583 | 0.396,0.860 | 0.006* |
aAdjusted for age, ORs and 95% CIs were calculated by logistic regression. * P<0.05.