Table 2. Multivariate analysis of overall survival and cancer-specific survival in the training cohort.

Variable	OS			CSS
	HR	95% CI	P	HR	95% CI	P
Age at diagnosis, years
< 20	ref			ref
20-39	1.603	1.443 to 1.781	< 0.001	1.521	1.334 to 1.735	< 0.001
40-59	3.885	3.498 to 4.316	< 0.001	2.802	2.455 to 3.199	< 0.001
≥ 60	13.845	12.493 to 15.343	< 0.001	7.473	6.565 to 8.507	< 0.001
Gender
Male	1.259	1.205 to 1.316	< 0.001	1.191	1.121 to 1.264	< 0.001
Female	ref			ref
Race
White	ref			ref
Black	1.358	1.269 to 1.454	< 0.001	1.481	1.357 to 1.616	< 0.001
Othersa	0.926	0.830 to 1.033	0.170	1.056	0.919 to 1.215	0.441
Ann Arbor stage
Stage I/II	ref			ref
Stage III/IV	1.705	1.632 to 1.781	< 0.001	2.058	1.937 to 2.187	< 0.001
Histological type
LR	ref			ref
MC	1.401	1.237 to 1.587	< 0.001	1.654	1.367 to 2.001	< 0.001
LD	2.305	1.959 to 2.713	< 0.001	3.146	2.493 to 3.972	< 0.001
NS	1.109	0.982 to 1.251	0.096	1.338	1.112 to 1.610	0.002
NOS	1.535	1.355 to 1.739	< 0.001	1.814	1.501 to 2.192	< 0.001

^aOthers includes American Indian/Alaskan Native and Asian/Pacific Islander.

Abbreviations: OS, overall survival; CSS, cancer-specific survival; HR, hazard ratio; CI, confidence interval; LR, lymphocyte-rich; MC, mixed cellularity; LD, lymphocyte-depleted; NS, nodular sclerosis; NOS, not otherwise specified; ref, reference.