Table 2. KEGG pathway analysis of differentially expressed genes.
| ID | Description | Gene count | P value | Genes | |
|---|---|---|---|---|---|
| Up-regulatde | 04110 | Cell cycle | 4 | 6.10E-03 | CCNB1, CDK1, CDKN2A, PTTG1 |
| 04115 | p53 signaling pathway | 3 | 1.69E-02 | CCNB1, CDK1, CDKN2A | |
| 04974 | Protein digestion and absorption | 3 | 2.73E-02 | COL4A1, COL15A1, COL1A2 | |
| 05146 | Amoebiasis | 3 | 4.19E-02 | COL4A1, COL1A2, PLCB1 | |
| 04919 | Thyroid hormone signaling pathway | 3 | 4.70E-02 | NOTCH3, PLCE1, PLCB1 | |
| Down-regulated | hsa04610 | Complement and coagulation cascades | 7 | 1.16E-04 | F11, C8A, C9, FGA, MASP1, F2, PLG |
| hsa01100 | Metabolic pathways | 26 | 1.53E-03 | NDST3, UPP2, ADH1B, GCH1, HK3, ST3GAL6, HAAO, CDA, RGN, DMGDH, AADAT, ST6GAL2, ASMT, CYP2C8, NAT2, HAL, CYP1A2, CYP2E1, GRHPR, DBH, PCK2, TAT, ACSM3, CTH, HMGCS2, UROC1 | |
| hsa05204 | Chemical carcinogenesis | 6 | 2.00E-03 | CYP3A43, CYP2C8, NAT2, ADH1B, CYP2E1, CYP1A2 | |
| hsa00380 | Tryptophan metabolism | 4 | 1.01E-02 | AADAT, ASMT, HAAO, CYP1A2 | |
| hsa01130 | Biosynthesis of antibiotics | 7 | 3.20E-02 | AADAT, CTH, HMGCS2, HK3, RGN, PCK2, TAT |
If there were more than five terms enriched in this category, top five terms were selected according to P value. Count: the number of enriched genes in each term.