Table 2.

Commonly described autoantibodies in Sjögren’s syndrome

Autoantibody	Prevalence (%)	Properties	Clinical association
Anti-Ro/SSA	50–70	Disease marker	Younger age at diagnosis Severe and extraglandular disease Pathogenic in congenital heart block
Anti-La/SSB	25–40	Disease marker	Extraglandular disease Pathogenic in congenital heart block
Rheumatoid factor	36–74	Phenotype marker	Extraglandular disease
Anti-CCP	3–10	Phenotype marker	Arthritis
Antimithocondrial antibodies	3–10	Phenotype marker	Elevated liver enzymes
Anticentromere antibodies	3–27	Phenotype marker	Raynaud’s phenomenon

SSA/SSB Sjögren’s-syndrome-related antigen A/B, CCP cyclic citrullinated peptide