Figure 1.

Mortality and myocardial regeneration. (A) Cytokine-treated infarcted mice, n = 15; untreated infarcted mice, n = 52; log-rank test, P < 0.0001. (B) Large infarct (MI) in a cytokine-treated mouse; forming myocardium (arrowheads) at higher magnification (adjacent panel). (C) MI in a nontreated mouse. Healing comprises the entire infarct (arrowheads). Scarring at higher magnification (adjacent panel). Red = cardiac myosin; yellow-green = propidium iodide (PI) labeling of nuclei; blue-magenta = collagen types I and III. (B and C, ×20; Insets, ×80.)