Table 1.

Effects of surfactants and drug/polymer ratios on nanoparticle characteristics

Surfactant	OP:EAP	Drug:PLGA	Particle size (nm)*	Zeta potential (mV)*	PDI*
1% PVA	1:5 (4 ml:20 ml)	1:5 (10 mg:50 mg)	3330.00±1.88	−13.3±3.3	0.869±0.094
2% SLS	1:4 (4 ml:16 ml)	1:10 (2.5 mg:25 mg)	340.60±5.15	−14.1±3.9	0.322±0.124
2% PVA	1:5 (4 ml:20 ml)	1:5 (10 mg:50 mg)	7300.00±1.70	−24.5±12.4	1.000±0.000
2% PVA	1:4 (4 ml:16 ml)	1:10 (5 mg:50 mg)	329.30±21.70	−17.4±7.1	0.355±0.040
1% SLS	1:4 (4 ml:16 ml)	1:10 (5 mg:50 mg)	3700.00±0.60	−16.6±22.5	0.653±0.122

^*Data are expressed as mean±SD (n=3); OP: organic phase; EAP: external aqueous phase; PVA: polyvinyl alcohol; SLS: sodium lauryl sulfate; PDI: polydispersity index