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. 2017 Nov 21;8:1649. doi: 10.1038/s41467-017-01897-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Mrg15 is required for proper deposition of Ash1 catalyzed H3K36me2 in S2 cells. a Heat maps show the H3K36me2 occupancy around Ash1 peaks in wild type, Ash1 knockdown and Mrg15 knockdown cells. All peaks were sorted according to H3K36me2 reads densities in wild-type cells. b Profiles of average normalized read densities (RP10M) show the H3K36me2 occupancy around Ash1 peaks in wild type, Ash1 knockdown and Mrg15 knockdown cells. c Boxplot of average normalized read densities (RPM per kb peak) of H3K36me2 occupancy at three subgroups of Ash1 peaks accompanied by high or low levels of Mrg15, respectively. d Scatter plot shows the distribution of Ash1 ChIP-seq signals at the first exons of the top 200 Ash1 target genes. Ash1 occupancy is not evenly distributed at these targets, with a subset of genes (the 26 super targets) containing exceptionally high levels of Ash1. e Scatter plot shows the mRNA level changes of the top 200 Ash1 target genes upon Ash1 knockdown. The 26 super target genes are marked in red. f The relative expression levels of 8 Ash1 top super target genes in wild type, Ash1 knockdown and Mrg15 knockdown cells