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. 2017 Nov 21;8:1637. doi: 10.1038/s41467-017-01534-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Mutations at the GBS or at the extended loop reduced binding of BoNT/DC-H_C to neurons. Experiments were carried out as described in Fig. 1d, with WT or the indicated mutants of BoNT/DC-H_C. Mutations at the GBS (Y1115F, S1275A, and G1241A) and a mutation at the extended loop (F1253A) all reduced binding of BoNT/DC-H_C to neurons. Y1165F/N1167A did not affect binding BoNT/DC-H_C to neurons. One of two independent experiments is shown