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. 2017 Nov 20;7:15851. doi: 10.1038/s41598-017-15975-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stabilization of the closed state reproduces the observed changes in inhibition. (A) Ca²⁺ inhibition data at different voltages was fitted using the linear Hill model. The discontinuous lines show the 95% confidence intervals of the model for the inhibition curves obtained at different voltages. (B) The points show the Log IC50 determined at different voltages. The black line indicates the prediction of the Log IC50 according to the linear Hill model, and the dotted lines show the 95% confidence intervals.