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. 2017 Nov 20;7:15851. doi: 10.1038/s41598-017-15975-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global fit of the data to the allosteric model with 6 Ca²⁺ binding sites. (A) G/Gmax vs voltage. (B) Ca²⁺ inhibition curves at different voltages. (C) Time constants vs voltage from activation and deactivation kinetics. (D) Time constants vs Ca²⁺ concentration from deactivation kinetics at −100 mV. Data is presented as mean ± SD. The lines of the fitting indicate the 95% confidence bands. To display the fitting, we draw 400 sets of parameters from the posterior distribution and the experimental results were simulated based on the proposed model with each parameter set.