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. 2017 Nov 20;7:15865. doi: 10.1038/s41598-017-16129-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological characterization of L6-S1 dorsal root ganglion (DRG) neurons that project to the bladder from SNS-Arch mice. (A,B & C) Immunohistochemical analysis of tissue from SNS-Arch mice confirms GFP reporter expression in L6-S1 DRGs. Labeling of bladder-innervating DRG neurons was achieved via bladder injections of the retrograde neuronal tracer cholera toxin B. Co-labeling of GFP and CTB-555 with the neuronal markers calcitonin gene related peptide (CGRP), neurofilament 200 (NF200) and isolectin B4 (IB4) reveal a mixed population of sensory neurons that innervate the mouse bladder; scale bar 100 μm (n = 2). (D) Whole mount staining of the bladder wall shows sensory neurons expressing GFP innervate the bladder wall of SNS-Arch mice and co-label with β3-tubulin; scale bar 100 μm.