Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 20;7:15856. doi: 10.1038/s41598-017-15977-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Immunohistochemical Staining of Sox9 in CP Subtypes and Summary of Calculated Sox9 Staining Scores. (a,b) Sox9 expression in aCP was not evenly distributed throughout the tumour, but rather showed significant regional differences (ada57). Although large proportions of the cells demonstrated a distinct nuclear staining pattern, small cell clusters in the direct vicinity were clearly negative. (c,d) Homogeneous and moderate immunohistochemical staining pattern of Sox9 in pCP (pap3, pap5). (e) The spikes illustrate the percentage shares of the immunohistochemical scoring groups (S1 = “no expression”; S2 = “low/moderate expression”; S3 = “strong expression”) within aCP and pCP specimens studied. Nuclear Sox9 staining was found in each of the 73 CP samples. Whereas all pCP samples showed only a moderate Sox9 expression (100% in group S2), aCP revealed expression in varying intensities (20.3% in group S2 and 79.7% in group S3) with a significantly higher overall Sox9 expression in this subtype [Fisher’s exact test (two-sided): p < 0.0001]. Exact values for each tumour sample were given in S-Table 1. (f) Sox9 mRNA expression analysis confirmed significantly enhanced levels in aCP (n = 26; mean = 24,47 in relation to pCP (n = 7; mean = 10,18; Mann-Whitney test, p = 0,0484).