Skip to main content
. 2017 Nov 21;11:356. doi: 10.3389/fncel.2017.00356

Figure 5.

Figure 5

The selective SK channel antagonists apamin and UCL1684 block ACh-sensitive currents in torus type II hair cells. (A,D) ACh-sensitive currents in torus type II hair cells acquired with the ramp protocol during the application of 100 μM ACh alone (open circles) or in the presence of 100 μM ACh with 500 nM apamin (A) or 100 nM UCL1684 (D). Currents in the presence of antagonists shown as filled circles. (B,E) Peak ACh-sensitive current at −20 mV in different type II hair cells are plotted before (ACh, open circles) and after apamin (APA) or UCL1684 (filled circles), respectively. (C,F) ACh-sensitive voltage changes recorded under zero-current, current-clamp conditions during the application of 100 μM ACh alone or 100 μM ACh with 1 μM apamin (C) or 100 nM UCL1684 (F). Arrowheads indicate post-hyperpolarization depolarization. Gap between traces in (F) represents segment of activity removed to allow side by side comparison.