Figure 1. Acute connectivity changes spatially relate to axonal damage.

(A) Frontal pole (FP) and anterior supramarginal gyrus (aSMG) are shown in yellow, with the probabilistic tractography connecting them shown in red. DTI_max region is overlaid in blue, showing the spatial relationship between structural abnormalities and resting-state fMRI connectivity. (B) Significant whole-brain region-to-region connectivity differences between controls and the 24- to 72-hour postconcussion (PC) group. Blue indicates a decrease and red indicates an increase in region-to-region connectivity. (C) Voxel-wise connectivity pattern using the right aSMG (green arrow) as a seed, displaying the enhanced anticorrelation (blue) with the FP and regions that mimic the default mode network. AG = angular gyrus; pPaHC = posterior parahippocampus; ROI = region of interest.