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. 2017 Nov 21;5:83. doi: 10.1186/s40425-017-0290-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Monitoring of circulating CD8⁺PD-1⁺ levels and impact on OS. a Circulating CD8⁺PD-1⁺ T cell levels before and during treatment. Effect of response groups and time points and their interaction were assessed with a one-way ANOVA group comparison using a linear mixed effects models for repeated measures; *: p < 0.05 between irPD and irPR + CR groups. b-c Kaplan-Meier OS curves for the CD8⁺PD-1⁺ T cell population, stratified by mean percentages at baseline (b, Pre) and each indicated time point (c). P values were calculated using the log-rank test and are shown on each graph