Table 6.

Comparison of the detailed sialoside receptor specificity of H3 influenza virus recHAs.

Glycans	Graph a	1968	1973	1975	1979	1986	1987	1992	1994	1995	1997	1999	2003	2004	2005	2007	2009	2011
α2–3
Sulfated b	4–8	.	.	.	.	.	.	.	.	+++	+++	.	.	.	.	.	.	.
Branched di-sialyl	9–12	.	+	+	.	.	.	+++	.	.	.	+	.	.	.	.	.	.
Linear	13–26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Fucosylated	27–34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Internal	35–40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
α2–6
Sulfated	41	+++	+++	+++	+++	+++	+++	+++	.	+++	+++	+++	.	.	.	.	.	.
Branched mono-sialyl	42	.	++	.	+	+++	+++	.	.	.	+	.	.	.	.	.	.	.
Branched di-sialyl	43–47	++	+++	++	+++	+++	+++	+++	++	+++	+++	+++	++	++	+	+	+	+
Linear (length) c
2	48–49	.	.	.	++	+++	+++	.	.	.	.	.	.	.	.	.	.	.
3	52–54	+	+++	.	+++	+++	+++	+	.	++	++	+++	.	.	.	.	.	.
4	55	+++	+++	.	+	+++	++	++	.	++	.	.	.	.	.	.	.	.
5	56	+	+++	++	+++	+++	+++	+++	+++	++	+++	+++	+++	+	.	.	.	+
6	57	.	++	.	++	+++	+++	+	+	+	+++	+++	+++	.	.	.	.	++
7	58–59	++	+++	++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++
Internal	60–61	.	+	.	.	+	.	+	.	.	.	.	.	.	.	.	.	.
Other
Sialic acid	1–3	.	+	.	+++	+++	+++	+	.	.	.	.	.	.	.	.	.	.
Mixed α2-3/α2-6	64–67	+	+++	+	+++	+++	+++	+++	.	+	++	+++	.	.	.	.	.	.
non-α2-3 or α2-6	68–88	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
asialo	89–96	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.

. No binding

^aMembers of each group are identified according to the graph number used in the microarray data in Fig 5 and correspond to numbers in the complete glycan list (supplemental Excel file).

^bBinding of samples to glycan subclasses are qualitatively estimated based on relative strength of the signal for the data shown in Fig 5: strong >10,000 (+++), medium >5000 (++), weak >1250 (+), no binding <1249 (.).

^cLength refers to the number of monosaccharides in the glycan chain, including SA.