Figure 1.

Primary spinal cord injury (SCI) biomechanics influence anatomical and functional recovery coincident with altered secondary injury cascades that serve as therapeutic targets.

Temporal associations of (A) anatomical/functional outcomes and (B) mediators of secondary injury after contusion SCI with or without residual compression illustrate the effect primary injury has on downstream events. Therapies may be differentially efficacious based on spinal cord injury modality. Values on the vertical axis represent relative changes and are not to scale. Curves were generated using data from Orr et al., (2017); Okon et al., (2013); Sjovold et al., (2013).