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. 2017 Oct;12(10):1687–1694. doi: 10.4103/1673-5374.217348

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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BBB score in rats with SCI at different time points.

Within 3 weeks after spinal cord hemisection, BBB scores increased gradually in rats from different groups, indicating gradual recovery of hindlimb locomotor function. From 7 days after injury, BBB scores were significantly greater in the PEI-ALG/Nis-siRNA group compared with the SCI group (*P < 0.05, **P < 0.01), SCI + PEI-ALG group (#P < 0.05), and SCI + PEI-ALG/Ctl-siRNA group (†P < 0.05). Data are expressed as the mean ± SEM (n = 6–8, two-way analysis of variance followed by Bonferroni multiple-comparison test). SCI: Spinal cord injury; PEI-ALG: polyethylenimine-alginate; Nis-siRNA: small interfering RNA targeting nischarin; Ctl: control; BBB: Basso, Beattie and Bresnahan locomotor rating.