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. 2017 Oct;12(10):1687–1694. doi: 10.4103/1673-5374.217348

Figure 4.

Figure 4

Effect of Nis-siRNA delivered by PEI-ALG nanoparticles on GAP-43 expression in the injured spinal cord of rats on day 21 after SCI.

(A) At 21 days after SCI, immunofluorescence staining was performed to examine GAP-43 expression. Scale bars: 100 μm. GAP-43-positive structures (arrows) were observed in the injured spinal cord. (B) Quantification of GAP-43 relative fluorescence intensity. GAP-43 expression was increased in the PEI-ALG/Nis-siRNA group compared with the SCI group (**P < 0.01), SCI+PEI-ALG group (##P < 0.01), and SCI + PEI-ALG/Ctl-siRNA group (††P < 0.01). Data are expressed as the mean ± SEM (n = 3; one-way analysis of variance followed by post hoc test). SCI: Spinal cord injury; PEI-ALG: polyethylenimine-alginate; Nis-siRNA: small interfering RNA targeting nischarin; Ctl: control; GAP-43: growth-associated protein-43.