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. 2017 Oct;12(10):1733–1741. doi: 10.4103/1673-5374.217353

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Summarized possible mechanisms between BDNF and GABAergic transmission during neurodegenerative process.

During neurodegenerative process, there is a close interaction between BDNF and GABAergic transmission. In inhibitory synapses, both increase and decrease in BDNF levels contribute to abnormal GABAergic transmission via alteration of GABA release and GAT-1-related transport of GABA, and abnormal regulation and decreased transcription of GABA_AR. It may interrupt the balance between excitatory/inhibitory neurotransmission, attributing to the underlying mechanisms of neurodegeneration. BDNF: Brain-derived neurotropic factor; Egr3: early growth response 3; GABA: gamma-aminobutyric acid; GABA_AR: GABA A receptors; GAD65/67: glutamic acid decarboxylase 65/67; GAT-1: GABA transporter 1; KCC2: K⁺-Cl⁻ cotransporter 2; PKC/MAPK: protein kinase C/mitogen-activated protein kinase; TrkB: tropomyosin receptor kinase B; VGAT: vesicular GABA transporter.