Skip to main content
. 2017 Apr 11;6(5):315–321. doi: 10.1002/psp4.12180

Figure 2.

Figure 2

Comparison of simulated (lines) and observed (points) plasma concentration–time profiles of desipramine following i.v. administration: (a) mean simulated Cp‐time profile after 12.5 mg i.v. bolus administration used for model building; (b) population simulation (mean, 2.5–97.5th percentiles) for 12.5 mg i.v. bolus administration used for model building; (c) mean simulated Cp‐time profile after 12.5 mg i.v. bolus administration without increased volume of distribution; (d) mean predicted Cp‐time profile for 50 mg i.v. bolus administration used for external model qualification; (e) population simulation (mean, 2.5–97.5th percentiles) for 50 mg i.v. bolus administration used for external model qualification. Observed data are obtained from refs. 22, 23.