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. 2017 Apr 11;6(5):315–321. doi: 10.1002/psp4.12180

Figure 3.

Figure 3

Comparison of simulated (lines) and observed (points) plasma concentration–time profiles of desipramine following oral administration: (a) mean simulated Cp‐time profile after 50 mg oral administration used for model building; (b) population simulation (mean, 2.5–97.5th percentiles) for 50 mg oral administration used for model building; (c) mean simulated Cp‐time profile after 50 mg oral administration with no phospholipid binding or lysosomal trapping in enterocytes; (d) mean predicted Cp‐time profile for 100 mg oral administration used for external model qualification; (e) population simulation (mean, 2.5–97.5th percentiles) for 100 mg oral administration used for external model qualification. Observed data are obtained from refs. 24, 25.