Table 1.
Six prognostic indexes for patients with non-small cell lung cancer with brain metastases
| Prognostic factors | RPA | SIR | BS-BM | GGS | DS-GPA | NSCLC-RADES |
|---|---|---|---|---|---|---|
| Sample | 1200 | 65 | 110 | 479 | 5067 | 514 |
| Age(years) | <65/≥65 | ≤50(2′), 51–59(1′), ≥60(0′) | _ | ≥65(1′), <65(0′) | <50(1′), 50–60(0.5′), >60(0′) | |
| gender | M (2′), F (5′) | |||||
| KPS (%) | ≥70/<70 | 80–100(2′), 60–70(1′), ≤50(0′) | 80–100(1′), ≤70(0′) | <70(1′), ≥70(0′) | 90–100(1′), 70–80(0.5′), <70(0′) | <70(1′), ≥70(5′) |
| CPT | Y/N | Y (1′), N (0′) | ||||
| ECM | Y/N | CR (2′), PR/stable (1′), PD (0′) | N (1′), Y (0′) | Y (1′), N (0′) | N (1′), Y (0′) | Y (2′), N (5′) |
| Vol. of BM(cm3) | _ | <5(2′), 5–13(1′), >13(0′) | _ | _ | _ | _ |
| Number of BM | _ | 1(2′), 2(1′), ≥3(0′) | _ | _ | 1(1′), 2–3(0.5′), >3(0′) | _ |
| Class I | All 4 favorable factors | 8–10’ | 3’ | 0’ | 0–1’ | 5–9’ |
| Class II | others | 4–7’ | 2’ | 1’ | 1.5–2’ | 11–12’ |
| Class III | KPS < 70 | 1–3’ | 1’ | 2’ | 2.5–3’ | 15’ |
| Class IV | 0’ | 3’ | 3.5–4’ |
RPA recursive partitioning analysis, SIR Score Index for Radiosurgery, BS-BM basic score for BM, GGS Golden Grading System, DS-GPA disease-specific graded prognostic assessment, CPT control of primary tumor, ECM extracranial metastases, BM brain metastases, Y yes, N no, M male, F female, KPS Karnofsky performance status, CR complete response, PR partial response, PD progressive disease