Table 1.
Baseline Characteristics of the patients diagnosed with PAP between 1993 and 2014 in Korea (n = 78)
| Variablesa | N = 78 |
|---|---|
| Classification | |
| Idiopathic | 75 (96.2) |
| Secondary | 3 (3.8) |
| Age (median years [IQR]) | 47.5 (42.5–59) |
| Male | 47 (60.3) |
| Smoking status (n = 73) | |
| Never-smoker | 34 (46.6) |
| Ex-smoker | 18 (24.6) |
| Current smoker | 21 (28.8) |
| Symptoms | |
| Symptomatic | 62 (79.5) |
| Asymptomatic | 16 (20.5) |
| Disease severity scoreb (n = 65) | |
| 1 | 9 (13.8) |
| 2 | 33 (50.8) |
| 3 | 16 (24.6) |
| 4 | 4 (6.2) |
| 5 | 3 (4.6) |
| Presence of dust exposure (n = 71) | 34 (47.9) |
| Extent of radiologic involvement | |
| Diffuse bilateral lung involvement | 32 (41.0) |
| Chest CT pattern (n = 50) | |
| Ground glass opacity (GGO) only | 18 (36.0) |
| GGO + crazy paving appearance | 32 (64.0) |
| FVC % predicted | 81.1 ± 16.6 |
| DLCO % predicted | 69.5 ± 25.2 |
| PaO2 mm Hg | 79.1 ± 24.7 |
| D(A-a)O2 mm Hg | 28.1 ± 15.2 |
| Hb g/dL | 14.1 ± 2.3 |
| LDH U/L | 419.3 ± 180.7 |
| CEA ng/mL | 7.0 ± 7.8 |
| Follow-up days (median [IQR]) | 677 (214–1588) |
IQR interquartile range, FVC forced vital capacity, DL CO diffusing capacity of the lung for carbon monoxide, Hb hemoglobin, LDH lactate dehydrogenase, CEA carcinoembryonic antigen
aParametric data are shown as means (± standard deviation) and nonparametric data as medians and interquartile ranges (IQRs). Dichotomous or discontinuous variables are presented as numbers (%)
bData on arterial blood gas analyses could not be obtained in 13 patients. The categories of score ranged from DSS 1 to DSS 5 as described previously17; DSS 1 = no symptoms and PaO2 ≥ 70 mmHg, DSS 2 = symptomatic and PaO2 ≥ 70 mmHg, DSS 3 = 60 mmHg ≤ PaO2 < 70 mmHg, DSS 4 = 50 mmHg ≤ PaO2 < 60 mmHg, DSS 5 = PaO2 < 50 mmHg