Table 2.

Dosing regimen for furosemide and torasemide in Study 1 and Study 2

Conversion table used in Study 1 at Day 0 for determining the initial dose of torasemide#
Theoretical dose of furosemide (evaluated by the clinical investigator)		1 mg/kg, 2 × /day	2 mg/kg, 2 × /day	3 mg/kg, 2 × /day	4 mg/kg, 2 × /day	5 mg/kg, 2 × /day
Initial dosage (Day 0) of the study treatments distributed by the therapist investigator	Furosemidea (Furosemide group)	1 mg/kg, 2 × /day	2 mg/kg, 2 × /day	3 mg/kg, 2 × /day	4 mg/kg, 2 × /day	5 mg/kg, 2 × /day
	Torasemideb (Torasemide group)	0.2 mg/kg, 1 × /day	0.4 mg/kg, 1 × /day		0.6 mg/kg, 1 × /day

Conversion table used in Study 2 at Day 0 for determining the initial dose of torasemide##
Theoretical dose of furosemide (evaluated by the clinical investigator)		1 mg/kg, 2 × /day	2 mg/kg, 2 × /day	3 mg/kg, 2 × /day	4 mg/kg, 2 × /day	5 mg/kg, 2 × /day
Initial dosage (Day 0) of the study treatments distributed by the therapist investigator	Furosemidea (Furosemide group)	1 mg/kg, 2 × /day	2 mg/kg, 2 × /day	3 mg/kg, 2 × /day	4 mg/kg, 2 × /day	5 mg/kg, 2 × /day
	Torasemidec (Torasemide group)	0.2 mg/kg, 1 × /day	0.3 mg/kg, 1 × /day	0.4 mg/kg, 1 × /day	0.5 mg/kg, 1 × /day	0.6 mg/kg, 1 × /day

^#Follow‐up from Day 0 to Day 84 ± 4 days: if judged necessary by the clinical investigator (depending on the animal's general clinical condition and all parameters recorded at each visit, i.e, physical parameters, CBC, biochemistry, and thoracic radiographs), increments of 1 mg/kg twice a day of furosemide (up to 5 mg/kg, 2x/day, according to the British Specific Product Characteristics^d) for dogs from the Furosemide group and increments of 0.2 mg/kg once a day of torasemide for dogs from the Torasemide group (up to 0.8 mg/kg/d).

^##Follow‐up from Day 0 to Day 84 ± 4 days: if judged necessary by the clinical investigator (depending on the animal's clinical condition and all parameters recorded at each visit (i.e, physical parameters, CBC, biochemistry, and thoracic radiographs), increments of 1 mg/kg twice a day of furosemide (up to 5 mg/kg, 2x/day, according to the British Specific Product Characteristics^d) for dogs from the Furosemide group and increments of 0.1 mg/kg once a day of torasemide for dogs from the Torasemide group (up to 0.6 mg/kg/d). The initial dose of 0.2 mg/kg once a day could also be decreased to 0.1 mg/kg once a day after Day 7.

^aBidivisible tablets containing 19 and 40 mg of furosemide.

^bBidivisible tablets containing 1.5, 4.5, and 12 mg of torasemide.

^cBidivisible tablets containing 0.75 mg of torasemide, and quadri‐divisible tablets containing 3.0, 7.5, and 18 mg of torasemide.