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. 2017 Sep 27;31(6):1804–1815. doi: 10.1111/jvim.14837

Figure 1.

Figure 1

(A–D) Trypan blue exclusion assay show that JAK inhibitors AZD1480 and CYT387 inhibit canine DLBCL cell growth in vitro. Canine diffuse large B‐cell lymphoma cell line CLBL‐1 and normal canine kidney cells (MDCK) were treated with AZD1480 or CYT387 at variable concentrations. DMSO‐treated cells were used as an internal control. The percentage of growth was normalized to the control treatment with DMSO. (E–H) Canine DLBCL cells CLBL‐1 are more sensitive to JAK inhibitors AZD1480 and CYT387 compared with canine normal kidney cells MDCK. The reduction of cell growth in CLBL‐1 cells was more significant compared to MDCK cells with 48 and 72‐hour drug treatments. The percentage of growth was normalized to the control treatment with DMSO (*P < 0.05; **P < 0.01; ***P < 0.001). Data were presented as mean ± SD.