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. 2017 Sep 27;31(6):1804–1815. doi: 10.1111/jvim.14837

Figure 5.

Figure 5

JAK inhibitors AZD1480 and CYT387 increase apoptosis in canine diffuse large B‐cell lymphoma cells (CLBL‐1). Representative flow cytometric analysis of AZD1480‐treated (A–C) and CYT387‐treated cells (D‐F) for early apoptosis (Annexin V+, SYTOX Red −), late apoptosis (Annexin V+, SYTOX Red+), and healthy cells (Annexin V−, SYTOX Red−). Compared with DMSO controlled treated cells, there was a significant increase in early apoptosis in canine DLBCL cell line CLBL‐1 treated with either AZD1480 or CYT387 (B, E). The increase in apoptosis in normal canine kidney cell line MDCK was minimal and not statistically significant (C, F). Data were presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001.