Table 3.
In vitro suseptibility patterns of Candida species isolates from Colonized (C) and Infected (I) patients
| Species Antifungal | I Ra |
I R% |
I GM |
I MIC90 (μg/ml) |
C Ra |
C R% |
C GM |
C MIC90 (μg/ml) |
Total ECV (μg/ml) |
Total Wild type (%) |
Total Non-wild type (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Candida albicans | |||||||||||
| AMB | 0.032-16 | 3.3 | 0.052 | 0.25 | 0.032-32 | 0.9 | 0.039 | 0.25 | 0.5 | ≤ 0.5(95%) | > 0.5(5%) |
| CAS | 0.032-1 | 0.5 | 0.03 | 0.25 | 0.032-1 | 0.4 | 0.041 | 0.125 | 0.25 | ≤ 0.25(98%) | > 0.25(2%) |
| VOR | 0.032-2 | 6.9 | 0.032 | 0.125 | 0.032-16 | 5.4 | 0.035 | 0.064 | 1 | ≤ 1(97%) | > 1(3%) |
| FLU | 0.032-64 | 4.9 | 0.254 | 2 | 0.032-64 | 0.5 | 0.254 | 2 | 4 | ≤ 4(96%) | > 4(4%) |
| POSa | 0.032-8 | – | 0.044 | 0.25 | 0.032-4 | – | 0.031 | 0.032 | 0.25 | ≤ 0.25(96%) | > 0.25(4%) |
| ITR | 0.032-16 | 12.7 | 0.104 | 1 | 0.032-16 | 2.6 | 0.049 | 0.125 | 1 | ≤ 1(98%) | > 1(2%) |
| Candida tropicalis | |||||||||||
| AMB | 0.032-8 | 18.4 | 0.115 | 4 | 0.032-0.5 | 0 | 0.033 | 0.125 | 1 | ≤ 1(95%) | > 1(5%) |
| CAS | 0.032-0.5 | 0 | 0.041 | 0.25 | 0.032-4 | 2.9 | 0.046 | 0.125 | 0.5 | ≤ 0.5(99%) | > 0.5(1%) |
| VOR | 0.032-16 | 14.3 | 0.056 | 1 | 0.032-16 | 8.3 | 0.033 | 0.125 | 1 | ≤ 1(96%) | > 1(4%) |
| FLU | 0.032-64 | 10.5 | 0.361 | 4 | 0.064-64 | 8.8 | 0.302 | 2 | 4 | ≤ 4(95%) | > 4(5%) |
| POS | 0.032-0.25 | – | 0.029 | 0.25 | 0.032-16 | – | 0.035 | 0. 125 | 0.25 | ≤ 0.25(95%) | > 0.25(5%) |
| ITR | 0.032-2 | 13.2 | 0.1 | 1 | 0.032-16 | 0 | 0.078 | 0.5 | 1 | ≤ 1(96%) | > 1(4%) |
| Candida glabrata | |||||||||||
| AMB | 0.032-16 | 11.1 | 0.101 | 8 | 0.032-0.5 | 0 | 0.031 | 0.064 | 0.5 | ≤ 0.5(99%) | > 0.5(1%) |
| CAS | 0.032-8 | 22.2 | 0.086 | 4 | 0.032-0.5 | 9.8 | 0.113 | 0.5 | 0.5 | ≤ 2 (96%) | > 2 (4%) |
| VOR | 0.16-4 | 0 | 0.088 | 2 | 0.032-0.5 | 0 | 0.05 | 0. 25 | 0.5 | ≤ 0.5 (96%) | > 0.5(4%) |
| FLU | 0.25 | 11.1 | 1.17 | 16 | 0.064-16 | 0 | 0.842 | 4 | 16 | ≤ 16 (98%) | > 16(2%) |
| POS | 0.032-16 | – | 0.179 | 8 | 0.032-16 | – | 0.082 | 0.5 | 4 | ≤ 4 (95%) | > 4(5%) |
| ITR | 0.032-16 | 77.8 | 0.739 | 4 | 0.032-16 | 15 | 0.233 | 1 | 2 | ≤ 2 (96%) | > 2(4%) |
| Candida famata | |||||||||||
| AMB | 0.032-2 | 5 | 0.038 | 0.25 | 0.032-1 | 0 | 0.037 | 0.25 | 0.25 | ≤ 0.25(95%) | > 0.25(5%) |
| CAS | 0.032-16 | 0 | 0.043 | 0.5 | 0.032-0.25 | 0 | 0.035 | 0.25 | 0.25 | ≤ 0.25(95%) | > 0.25(5%) |
| VOR | 0.032-0.5 | 0 | 0.024 | 0.5 | 0.032-1 | 0 | 0.034 | 0.125 | 0.25 | ≤ 0.5(98%) | > 0.5(2%) |
| FLU | 0.064-8 | 0 | 0.278 | 0.5 | 0.032-8 | 0 | 0.268 | 0.5 | 1 | ≤ 1(95%) | > 1(5%) |
| POS | 0.032-1 | – | 0.026 | 0.5 | 0.032-0.5 | 0 | 0.031 | 0.064 | 0.5 | ≤ 0.5(98%) | > 0.5(2%) |
| ITR | 0.032-1 | 10 | 0.081 | 0.5 | 0.032-1 | 4.3 | 0.062 | 0.5 | 0.5 | ≤ 0.5(98%) | > 0.5(2%) |
| Candida parapsilopsis | |||||||||||
| AMB | 0.032-0.5 | 0 | 0.023 | 0.032 | 0.032-0.25 | 0 | 0.027 | 0.032 | 0.25 | ≤ 0.25(95%) | > 0.25(5%) |
| CAS | 0.032-0.25 | 0 | 0.037 | 4 | 0.032-4 | 0 | 0.283 | 0.125 | 0.125 | ≤ 4(98%) | > 4(2%) |
| VOR | 0.032-0.032 | 0 | 0.017 | 0.032 | 0.032-0.25 | 0 | 0.025 | 0.032 | 0.032 | ≤ 0.032(96%) | > 0.032(4%) |
| FLU | 0.064-8 | 2.9 | 0.402 | 4 | 0.064-2 | 0 | 0.298 | 2 | 2 | ≤ 2(100%) | > 2(00%) |
| POS | 0.032-0.032 | – | 0.017 | 0.032 | 0.032-0.5 | – | 0.03 | 0.032 | 0.032 | ≤ 0.032(96%) | > 0.032(4%) |
| ITR | 0.032-0.5 | 0 | 0.0102 | 0.5 | 0.032-0.032 | 0 | 0.02 | 0.125 | 0.5 | ≤ 0.5(100%) | > 0.5(00%) |
| Candida kefyr | |||||||||||
| AMB | 0.032-1 | 0 | 0.045 | 1 | 0.032-1 | 0 | 0.03 | 0.064 | 1 | ≤ 1(99%) | > 1(1%) |
| CAS | 0.032-0.125 | 0 | 0.028 | 0.25 | 0.032-2 | 0 | 0.031 | 0.25 | 0.125 | ≤ 0.25(95%) | > 0.25(5%) |
| VOR | 0.032-0.032 | 0 | 0.018 | 0.032 | 0.032-0.125 | 0 | 0.021 | 0.032 | 0.032 | ≤ 0.032(96%) | > 0.032(4%) |
| FLU | 0.25-0.5 | 0 | 0.397 | 1 | 0.064-2 | 0 | 0.185 | 0.5 | 1 | ≤ 1(96%) | > 1(4%) |
| POS | 0.032-0.032 | – | 0.018 | 0.032 | 0.032-0.125 | – | 0.021 | 0.032 | 0.032 | ≤ 0.032(96%) | > 0.032(4%) |
| ITR | 0.032-0.125 | 0 | 0.032 | 0.125 | 0.032-0.25 | 0 | 0.037 | 0.125 | 0.125 | ≤ 0.125(96%) | > 0.125(96%) |
| Candida krusei b | |||||||||||
| AMB | 0.032-8 | 40 | 1.004 | 8 | 0.032-4 | 40 | 0.386 | 4 | 4 | ≤ 4(95%) | > 4(5%) |
| CAS | 0.032-2 | 30 | 0.2 | 2 | 0.032-0.5 | 0 | 0.092 | 0.25 | 2 | ≤ 2(99%) | > 2(1%) |
| VOR | 0.032-16 | 20 | 0.284 | 2 | 0.032-16 | 7.7 | 0.235 | 0.5 | 2 | ≤ 2(95%) | > 2(5%) |
| FLU | 2-64 | – | 17.9 | 64 | 0.25-64 | – | 6.817 | 64 | 64 | ≤ 64(95%) | > 64(5%) |
| POS | 0.032-0.5 | – | 0.126 | 0.5 | 0.032-16 | – | 0.214 | 0.5 | 0.5 | ≤ 0.5(95%) | > 0.5(5%) |
| ITR | 0.064-1 | 33.3 | 0.2 | 2 | 0.064-16 | 15.4 | 0.346 | 1 | 2 | ≤ 2(95%) | > 2(5%) |
| Other Candida spp.c | |||||||||||
| AMB | 0.032-0.032 | 0 | 0.032 | 0.032 | 0.032-1 | 0 | 0.032 | 0.064 | 0.064 | ≤ 0.064(95%) | > 0.064(95%) |
| CAS | 0.032-0.064 | 0 | 0.021 | 0.064 | 0.032-1 | 0 | 0.064 | 0.064 | 0.064 | ≤ 0.064(95%) | > 0.064(95%) |
| VOR | 0.032-0.032 | 0 | 0.032 | 0.032 | 0.032-0.125 | 0 | 0.026 | 0.032 | 0.125 | ≤ 0.125(100%) | > 0.125(100%) |
| FLU | 0.0125-4 | 0 | 0.33 | 4 | 0.064-8 | 0 | 0.227 | 0.5 | 4 | ≤ 4(95%) | > 4(95%) |
| POS | 0.032-0.032 | 0 | 0.032 | 0.032 | 0.032-0.064 | 0 | 0.023 | 0.032 | 0.032 | ≤ 0.032(95%) | > 0.032(95%) |
| ITR | 0.032-0.0125 | 0 | 0.024 | 0.125 | 0.032-0. 25 | 0 | 0.042 | 0.25 | 0.25 | ≤ 0.25(100%) | > 0.25(100%) |
Ra Range, MIC minimum inhibitory concentration, R resistant, MIC 90 Lowest concentration at which 90% of the isolates are inhibited
aPosaconazole has no breakpoint in new CLSI
bIsolates of C. krusei are considered resistant to fluconazole, irrespective of the MIC
cOthers: include; C. intermedia, C. dubliniensis, C. lusitaniae and M. guilliermondii (C. guilliermondii)